Associate Director, Translational Medicine, R&D Oncology, ADC

AstraZeneca - Waltham, MA - Associate Director, Translational Medicine, R&D Oncology, ADC Location: Waltham, MA USA At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. We are seeking a Translational Medicine Lead in Oncology R&D to join a world class center for discovery and development of innovative cancer medicines. In this role you will be accountable for delivery of robust, scientifically-driven biomarkers in drug discovery and development programs for hematology-oncology programs. You will have the opportunity to impact a growing portfolio of Antibody Drug Conjugate (ADC) programs from inception through to life cycle management for marketed drugs. Key Responsibilities and Accountabilities: In partnership with the Translational Medicine team, lead the implementation of strategic vision that enables target identification, indication selection, early indication of biological activity and patient stratification/selection in Oncology. Deliver biomarkers for clinical studies based on the best available science and technologies. Generate biomarker data to guide indication selection and identification of targeted patient populations. Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules. Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations. Define novel mechanisms of resistance targeted therapies by studying tumors at relapse. Collaborate with Oncology Research and product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early phases of development in Oncology. Collaborate with clinical operations teams to implement exploratory sample collection and analyses in clinical studies related to oncology. Manage internal and external research collaborations in areas of clinical technologies and oncology translational research. Ensure complex clinical assays developed and validated internally or externally are fit for purpose. Contribute to and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management. Essential Requirements and Qualifications Education Required: MD or PhD in a scientific discipline plus >7 years of experience Oncology training is required, preferably board certified or board eligible Experience Required: Extensive experience in drug development in pharmaceutical or biotech industries In-depth knowledge of oncology disease area biology and translational science, ideally with expertise in immuno-oncology and/or antibody drug conjugates. Proven communication, presentation and influencing skills. Highly developed problem solving and risk management skills. Ability to drive, manage, execute and deliver results for complex multi-functional projects. Highly developed collaborative working skills. Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca. Proven ability to motivate and develop others. Why AstraZeneca? At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, groundbreaking cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.... - Permanent - Full-time

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